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Article

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase.

Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2010

Gong Peng, Peersen Olve B

Abstract excerpt

Positive-strand RNA viruses include a large number of human and animal pathogens whose essential RNA-dependent RNA polymerases (RdRPs) share a structurally homologous core with an encircled active site. RdRPs are targets for antiviral drug development, but these efforts are hindered by limited structural information about the RdRP catalytic cycle. To further our understanding of RdRP function, we assembled,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21148772
DOI: 10.1073/pnas.1007626107
PMCID: PMC3012486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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