Article
Hepatitis E virus RNA-dependent RNA polymerase is involved in RNA replication and infectious particle production.
Hepatology (Baltimore, Md.) - 1 Jan 2022
Oechslin Noémie, Da Silva Nathalie, Szkolnicka Dagmara, Cantrelle François-Xavier, Hanoulle Xavier, Moradpour Darius, Gouttenoire Jérôme
Abstract excerpt
BACKGROUND AND AIMS: Hepatitis E virus (HEV) is one of the most common causes of acute hepatitis worldwide. Its positive-strand RNA genome encodes three open reading frames (ORF). ORF1 is translated into a large protein composed of multiple domains and is known as the viral replicase. The RNA-dependent RNA polymerase (RDRP) domain is responsible for the synthesis of viral RNA. APPROACH AND RESULTS: Here, we...
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