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Article

An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase.

Nucleic acids research - 7 Sept 2021

Zhang Bu-Yu, Liu Weichi, Jia Hengxia, Lu Guoliang, Gong Peng

Abstract excerpt

Viral RNA-dependent RNA polymerases (RdRPs) play central roles in the genome replication and transcription processes of RNA viruses. RdRPs initiate RNA synthesis either in primer-dependent or de novo mechanism, with the latter often assisted by a 'priming element' (PE) within the RdRP thumb domain. However, RdRP PEs exhibit high-level structural diversity, making it difficult to reconcile their conserved function...

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Identifiers

PMID: 34365500
DOI: 10.1093/nar/gkab666
PMCID: PMC8421227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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