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Article

A template RNA entry channel in the fingers domain of the poliovirus polymerase.

Journal of molecular biology - 6 Apr 2012

Kortus Matthew G, Kempf Brian J, Haworth Kevin G, Barton David J, Peersen Olve B

Abstract excerpt

Positive-strand RNA viruses within the Picornaviridae family express an RNA-dependent RNA polymerase, 3D(pol), that is required for viral RNA replication. Structures of 3D(pol) from poliovirus, coxsackievirus, human rhinoviruses, and other picornaviruses reveal a putative template RNA entry channel on the surface of the enzyme fingers domain. Basic amino acids and tyrosine residues along this entry channel are...

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Identifiers

PMID: 22321798
DOI: 10.1016/j.jmb.2012.01.049
PMCID: PMC3325025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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