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Article

Prevalence of antifolate drug resistance markers in Plasmodium vivax in China.

Frontiers of medicine - 1 Feb 2022

Huang Fang, Cui Yanwen, Yan He, Liu Hui, Guo Xiangrui, Wang Guangze, Zhou Shuisen, Xia Zhigui

Abstract excerpt

The dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) genes of Plasmodium vivax, as antifolate resistance-associated genes were used for drug resistance surveillance. A total of 375 P. vivax isolates collected from different geographical locations in China in 2009-2019 were used to sequence Pvdhfr and Pvdhps. The majority of the isolates harbored a mutant type allele for Pvdhfr (94.5%) and...

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PMID: 35257293
DOI: 10.1007/s11684-021-0894-x

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