Article
Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences.
Molecular and cellular biology - 1 Nov 1996
Matynia A, Dimitrov K, Mueller U, He X, Sazer S
Abstract excerpt
spi1p of Schizosaccharomyces pombe is a structural homolog of the mammalian GTPase Ran. The distribution between the GTP- and GDP-bound forms of the protein is regulated by evolutionarily conserved gene products, rna1p and pim1p, functioning as GTPase-activating protein (GAP) and guanine nucleoti...
Topics
- Animals
- Antibodies
- Antibody Specificity
- Chromatin
- Fungal Proteins
- GTP Phosphohydrolases
- GTP-Binding Proteins
- GTPase-Activating Proteins
- Genes, Fungal
- Genes, Lethal
- Guanine Nucleotide Exchange Factors
- Mammals
- Nuclear Proteins
- Phenotype