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Inhibitory Effects of Human β-Defensin 3 on <em>Porphyromonas gingivalis </em>Lipopolysaccharide-Induced Il-1β Production by Bv-2 Microglia through Suppression of Cathepsins B and L

2023-12-26

Abstract excerpt

Cathepsin B (CatB) is thought to be essential for the induction of Porphyromonas gingivalis lipopolysaccharide (Pg LPS)-induced Alzheimer’s disease- like pathologies in mice, including interleukin-1β (IL-1β) production and cognitive decline. However, little is known about the role of CatB in Pg virulence factor-induced IL-1β production by microglia. We first subjected IL-1β-luciferase reporter BV-2 microglia to in...

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Literature Corpus work
22bb1055-f8f3-5398-b097-126c8db48196
DOI
10.20944/preprints202312.1924.v1
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Inhibitory Effects of Human β-Defensin 3 on <em>Porphyromonas gingivalis </em>Lipopolysaccharide-Induced Il-1β Production by Bv-2 Microglia through Suppression of Cathepsins B and LDOI 10.20944/preprints202312.1924.v1
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