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Article

Recombinant streptavidin-C3bot for delivery of proteins into macrophages.

Toxicon : official journal of the International Society on Toxinology - 1 Dec 2013

Christow Hannes, Lillich Maren, Sold Alexander, Fahrer Jörg, Barth Holger

Abstract excerpt

We demonstrated previously that monocytes and macrophages are target cells for the Rho-modifying Clostridium botulinum C3 ADP-ribosyltransferase. Here, we report the construction, expression and characterization of a recombinant streptavidin-C3 fusion protein which allows for delivery of biotin-labelled molecules into the cytosol of macrophages via enzymatically inactive C3bot1E174Q. The enzyme domain of...

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Identifiers

PMID: 23422352
DOI: 10.1016/j.toxicon.2013.02.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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