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Article

Exogenous NT-3 Promotes Phenotype Switch of Resident Macrophages and Improves Sciatic Nerve Injury through AMPK/NF-κB Signaling Pathway.

Neurochemical research - 1 Sept 2024

Sun Xuri, Ni Shuqin, Zhou Qingsheng, Zou Dexin

Abstract excerpt

Neurotrophin-3 (NT-3) is an important family of neurotrophic factors with extensive neurotrophic activity, which can maintain the survival and regeneration of nerve cells. However, the mechanism of NT-3 on macrophage phenotype transformation after sciatic nerve injury is not clear. In this study, we constructed a scientific nerve compression injury animal model and administered different doses of NT-3 treatment...

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PMID: 38904909
DOI: 10.1007/s11064-024-04198-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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