Article
The axonal localization of large Drosophila ankyrin2 protein isoforms is essential for neuronal functionality.
Molecular and cellular neurosciences - 1 May 2002
Hortsch Michael, Paisley Kerry L, Tian Ming-Zhu, Qian Min, Bouley Michael, Chandler Robert
Abstract excerpt
In polarized cells, such as neurons, ankyrin-type proteins are the major molecules that link the actin-spectrin-based membrane cytoskeleton to the plasma membrane. In Drosophila the second ankyrin gene, Dank2, is exclusively expressed in neuronal cells. Similar to ankyrin genes in other organisms, the Dank2 gene generates several ankyrin protein isoforms by differential splicing. Here we report that in...
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