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Article

σ2-Adaptin Facilitates Basal Synaptic Transmission and Is Required for Regenerating Endo-Exo Cycling Pool Under High-Frequency Nerve Stimulation in Drosophila.

Genetics - 1 May 2016

Choudhury Saumitra Dey, Mushtaq Zeeshan, Reddy-Alla Suneel, Balakrishnan Sruthi S, Thakur Rajan S, Krishnan Kozhalmannom S, Raghu Padinjat, Ramaswami Mani, Kumar Vimlesh

Abstract excerpt

The functional requirement of adapter protein 2 (AP2) complex in synaptic membrane retrieval by clathrin-mediated endocytosis is not fully understood. Here we isolated and functionally characterized a mutation that dramatically altered synaptic development. Based on the aberrant neuromuscular junction (NMJ) synapse, we named this mutation angur (a Hindi word meaning "grapes"). Loss-of-function alleles of angur...

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Identifiers

PMID: 26920756
DOI: 10.1534/genetics.115.183863
PMCID: PMC4858786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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