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Article

Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome.

Cell reports - 25 Jul 2023

Yoon Sehyoun, Santos Marc Dos, Forrest Marc P, Pratt Christopher P, Khalatyan Natalia, Mohler Peter J, Savas Jeffrey N, Penzes Peter

Abstract excerpt

Rare genetic variants in ANK2, which encodes ankyrin-B, are associated with neurodevelopmental disorders (NDDs); however, their pathogenesis is poorly understood. We find that mice with prenatal deletion in cortical excitatory neurons and oligodendrocytes (Ank2-/-:Emx1-Cre), but not with adolescent deletion in forebrain excitatory neurons (Ank2-/-:CaMKIIα-Cre), display severe spontaneous seizures, increased...

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Ankyrins
Calcium
Mice
Mice, Knockout
Prosencephalon

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PMID: 37428632
DOI: 10.1016/j.celrep.2023.112784
PMCID: PMC10566302

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