Article
The specificity of binding of glycoprotein hormones to their receptors.
Cellular and molecular life sciences : CMLS - 1 Aug 2008
Caltabiano G, Campillo M, De Leener A, Smits G, Vassart G, Costagliola S, Pardo L
Abstract excerpt
The glycoprotein hormone receptor family is peculiar because, in contrast to other G protein-coupled receptors, a large N-terminal extracellular ectodomain is responsible for hormone recognition. Hormone-receptor pairs have evolved in such a manner that a limited number of positions both at the 'seat-belt' domain of the hormone and the leucine-rich repeats of the receptor, play attractive and repulsive...
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