Article
A molecular dissection of the glycoprotein hormone receptors.
Trends in biochemical sciences - 1 Mar 2004
Vassart Gilbert, Pardo Leonardo, Costagliola Sabine
Abstract excerpt
In glycoprotein hormone receptors, a subfamily of rhodopsin-like G protein-coupled receptors, the recognition and activation steps are carried out by separate domains of the proteins. Specificity of recognition of the hormones thyrotropin (TSH), lutropin (LH), human chorionic gonadotropin (hCG) and follitropin (FSH) involves leucine-rich repeats (LRRs) present in an N-terminal ectodomain, and can be associated...
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