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Article

Identification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling.

International journal of molecular sciences - 25 Dec 2020

Lazzaretti Clara, Secco Valentina, Paradiso Elia, Sperduti Samantha, Rutz Claudia, Kreuchwig Annika, Krause Gerd, Simoni Manuela, Casarini Livio

Abstract excerpt

(1) The human luteinizing hormone (LH)/chorionic gonadotropin (hCG) receptor (LHCGR) discriminates its two hormone ligands and differs from the murine receptor (Lhr) in amino acid residues potentially involved in qualitative discerning of LH and hCG. The latter gonadotropin is absent in rodents. The aim of the study is to identify LHCGR residues involved in hCG/LH discrimination. (2) Eight LHCGR cDNAs were...

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Identifiers

PMID: 33375708
DOI: 10.3390/ijms22010151
PMCID: PMC7794846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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