Thyrotropin receptor, still much to be learned from the patients.

Abstract excerpt

In the absence of crystal available for the full-length thyrotropin receptor, knowledge of its structure and functioning has benefitted from the identification and characterization of mutations in patients with various thyroid dysfunctions. The characterization of activating mutations has contributed to the elaboration of a model involving the extracellular domain of the receptor as an inverse tethered agonist...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mutation
• Share to Receptors, Thyrotropin
• Share to Signal Transduction