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Article

Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.

PloS one - 1 Jan 2014

Schaarschmidt Jörg, Huth Sandra, Meier René, Paschke Ralf, Jaeschke Holger

Abstract excerpt

Glycoprotein hormone receptors (GPHR) have a large extracellular domain (ECD) divided into the leucine rich repeat (LRR) domain for binding of the glycoprotein hormones and the hinge region (HinR), which connects the LRR domain with the transmembrane domain (TMD). Understanding of the activation mechanism of GPHRs is hindered by the unknown interaction of the ECD with the TMD and the structural changes upon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25340405
DOI: 10.1371/journal.pone.0111570
PMCID: PMC4207802

Genes

FSHR
TSHR
ECD
LHCGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.PMID 25340405Read ↗

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