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Article

H2AX: the histone guardian of the genome.

DNA repair - 1 Jan 2000

Fernandez-Capetillo Oscar, Lee Alicia, Nussenzweig Michel, Nussenzweig André

Abstract excerpt

At close hand to one's genomic material are the histones that make up the nucleosome. Standing guard, one variant stays hidden doubling as one of the core histones. But, thanks to its prime positioning, a variation in the tail of H2AX enables rapid modification of the histone code in response to DNA damage. A role for H2AX phosphorylation has been demonstrated in DNA repair, cell cycle checkpoints, regulated gene...

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Identifiers

PMID: 15279782
DOI: 10.1016/j.dnarep.2004.03.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer TherapySemantic proximity Read ↗

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