Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals

26 Jul 2016

Abstract excerpt

The biosynthesis of enveloped viruses depends heavily on the host cell endoplasmic reticulum (ER) glycoprotein quality control (QC) machinery. This dependency exceeds the dependency of host glycoproteins, offering a window for the targeting of ERQC for the development of broad-spectrum antivirals. We determined small-angle X-ray scattering (SAXS) and crystal structures of the main ERQC enzyme, ER α-glucosidase II...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mosquito-borne diseases and control
Share to Toxoplasma gondii Research Studies
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27462106
DOI: 10.1073/pnas.1604463113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antiviralsPMID 27462106Read ↗

Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic site.Semantic proximity Read ↗

Structural biology of dengue virus enzymes: Towards rational design of therapeuticsSemantic proximity Read ↗

Norovirus Protease Structure and Antivirals Development.Semantic proximity Read ↗

Targeting host-virus interactions: in silico analysis of the binding of human milk oligosaccharides to viral proteins involved in respiratory infectionsSemantic proximity Read ↗

Pharmacological chaperones for human α- <i>N</i> -acetylgalactosaminidaseSemantic proximity Read ↗

Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteasesSemantic proximity Read ↗

Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate.Semantic proximity Read ↗

Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain SpeciesSemantic proximity Read ↗

Unraveling the anti-dengue viral potential of protease inhibitors from Streptomyces spp.Semantic proximity Read ↗

Proteochemometrics mapping of the interaction space for retroviral proteases and their substrates.Semantic proximity Read ↗

Alphavirus protease inhibitors from natural sources: A homology modeling and molecular docking investigationSemantic proximity Read ↗

A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpointSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.