Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency in virion secretion and decreased stability of the hepatitis B virus immune escape mutant G145R.

Hepatology (Baltimore, Md.) - 1 Nov 2003

Kalinina Tatyana, Iwanski Alicja, Will Hans, Sterneck Martina

Abstract excerpt

Hepatitis B virus with a G145R mutation in the small surface protein is considered the quintessential immune escape mutant because it frequently is found in vaccinated individuals with breakthrough infections and liver transplant recipients under anti-hepatitis B surface antigen (HBsAg) immunoglobulin prophylaxis. Nowadays the prevalence of the variant progressively increases. However, because spread of a virus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemical Phenomena
Share to Chemistry, Physical

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Culture Media

Share to Detergents

Share to Homeostasis

Share to Octoxynol

Share to Polyethylene Glycols

Share to Virion

Source

Identifiers

PMID: 14578867
DOI: 10.1053/jhep.2003.50484

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency in virion secretion and decreased stability of the hepatitis B virus immune escape mutant G145R.PMID 14578867Read ↗

Modulation of hepatitis B virus secretion by naturally occurring mutations in the S gene.Semantic proximity Read ↗

A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis.Semantic proximity Read ↗

Impaired virion secretion by hepatitis B virus immune escape mutants and its rescue by wild-type envelope proteins or a second-site mutation.Semantic proximity Read ↗

Selection of a secretion-incompetent mutant in the serum of a patient with severe hepatitis B.Semantic proximity Read ↗

GLY145ARG mutation emerging under HBIG treatment in patients with recurrent HBV after liver transplantation strongly reduces viral secretion.Semantic proximity Read ↗

Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.Semantic proximity Read ↗

Infections by hepatitis B surface antigen gene mutants in Europe and North America.Semantic proximity Read ↗

Impacts of the G145R Mutation on the Structure and Immunogenic Activity of the Hepatitis B Surface Antigen: A Computational AnalysisSemantic proximity Read ↗

Hepatitis B caused by a hepatitis B surface antigen escape mutant.Semantic proximity Read ↗

Replicative competence of the T131I, K141E, and G145R surface variants of hepatitis B Virus.Semantic proximity Read ↗

A unique amino acid substitution, L215Q, in the hepatitis B virus small envelope protein of a genotype F isolate that inhibits secretion of hepatitis B virus subviral particles.Semantic proximity Read ↗

Mutations of the surface protein of hepatitis B virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.