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Decreased Methylation of the Mitochondrial D-Loop Region in Late-Onset Alzheimer’s Disease

23 Jun 2017

Abstract excerpt

Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might be involved in late-onset Alzheimer's disease (LOAD), but evidence in humans is limited. We assessed the methylation levels of the mtDNA D-loop region in blood DNA from 133 LOAD patients and 130 controls, observing a significant 25% reduction of DNA...

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PMID: 28655136
DOI: 10.3233/jad-170139

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