Article
Association study on glutathione S-transferase omega 1 and 2 and familial ALS.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 Apr 2008
van de Giessen Elsmarieke, Fogh Isabella, Gopinath Sumana, Smith Bradley, Hu Xun, Powell John, Andersen Peter, Nicholson Garth, Al Chalabi Ammar, Shaw Christopher E
Abstract excerpt
Glutathione S-transferase omega 1 and 2 (GSTO1 and 2) protect from oxidative stress, a possible pathogenic mechanism underlying the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Significant association of age of onset in Alzheimer's patients with GSTO1 and 2 had recently been identified, suggesting a possibly similar association with ALS. In this...
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