Article
Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications.
Molecular neurodegeneration - 11 Apr 2012
Allen Mariet, Zou Fanggeng, Chai High Seng, Younkin Curtis S, Miles Richard, Nair Asha A, Crook Julia E, Pankratz V Shane, Carrasquillo Minerva M, Rowley Christopher N, Nguyen Thuy, Ma Li, Malphrus Kimberly G, Bisceglio Gina, Ortolaza Alexandra I, Palusak Ryan, Middha Sumit, Maharjan Sooraj, Georgescu Constantin, Schultz Debra, Rakhshan Fariborz, Kolbert Christopher P, Jen Jin, Sando Sigrid B, Aasly Jan O, Barcikowska Maria, Uitti Ryan J, Wszolek Zbigniew K, Ross Owen A, Petersen Ronald C, Graff-Radford Neill R, Dickson Dennis W, Younkin Steven G, Ertekin-Taner Nilüfer
Abstract excerpt
BACKGROUND: Glutathione S-transferase omega-1 and 2 genes (GSTO1, GSTO2), residing within an Alzheimer and Parkinson disease (AD and PD) linkage region, have diverse functions including mitigation of oxidative stress and may underlie the pathophysiology of both diseases. GSTO polymorphisms were previously reported to associate with risk and age-at-onset of these diseases, although inconsistent follow-up study...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.