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Article

Thioredoxin reductase 1 haplotypes modify familial amyotrophic lateral sclerosis onset.

Free radical biology & medicine - 15 Jan 2009

Mitchell John, Morris Alex, de Belleroche Jacqueline

Abstract excerpt

Thioredoxin reductase 1 is a key enzyme in cellular redox processes, which are known to play a role in the pathogenesis of familial amyotrophic lateral sclerosis (FALS). The gene TXNRD1 was therefore screened for association with FALS. Resequencing of the exons and flanking regions identified 19 single-nucleotide polymorphisms (SNPs) of which 2, the intronic SNPs rs6539137 and rs4630362, were significantly...

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Identifiers

PMID: 18996185
DOI: 10.1016/j.freeradbiomed.2008.09.041

Genes

TXNRD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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