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Article

Role of glutathione S-transferases in the spinocerebellar ataxia type 2 clinical phenotype.

Journal of the neurological sciences - 15 Jun 2014

Almaguer-Gotay D, Almaguer-Mederos L E, Aguilera-Rodríguez R, Estupiñán-Rodríguez A, González-Zaldivar Y, Cuello-Almarales D, Laffita-Mesa J M, Vázquez-Mojena Y

Abstract excerpt

Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative and incurable hereditary disorder caused by a CAG repeat expansion mutation on ATXN2 gene. The identification of reliable biochemical markers of disease severity is of paramount significance for the development and assessment of clinical trials. In order to evaluate the potential use of glutathione-S-transferase (GST) activity as a biomarker for SCA2, a...

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Identifiers

PMID: 24780439
DOI: 10.1016/j.jns.2014.03.045

Genes

ATXN2

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