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Article

Association of glutathione S-transferase omega polymorphism and spinocerebellar ataxia type 2.

Journal of the neurological sciences - 15 Jan 2017

Almaguer-Mederos Luis E, Almaguer-Gotay Dennis, Aguilera-Rodríguez Raúl, González-Zaldívar Yanetza, Cuello-Almarales Dany, Laffita-Mesa José, Vázquez-Mojena Yaimé, Zayas-Feria Pedro, Rodríguez-Labrada Roberto, Velázquez-Pérez Luis, MacLeod Patrick

Abstract excerpt

BACKGROUND: Spinocerebellar ataxia type 2 is a neurodegenerative disorder caused by a CAG repeat expansion in ATXN2 gene. There is high clinical variability among affected patients suggesting the occurring of modifier genes influencing the clinical phenotype. OBJECTIVE: The objective is to assess the association of GSTO1 rs4925 and GSTO2 rs2297235 SNPs on the clinical phenotype in SCA2 patients. METHODS: A...

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Identifiers

PMID: 28017238
DOI: 10.1016/j.jns.2016.11.075

Genes

GSTO2
GSTO1
ATXN2

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