Article
Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases.
Pharmacogenetics and genomics - 1 Jul 2005
Schmuck Erica M, Board Philip G, Whitbread Astrid K, Tetlow Natasha, Cavanaugh Juleen A, Blackburn Anneke C, Masoumi Amir
Abstract excerpt
There are two functional Omega class glutathione transferase (GST) genes in humans. GSTO1 is polymorphic with several coding region alleles, including an A140D substitution, a potential deletion of E155 and an E208K substitution. GSTO2 is also polymorphic with an N142D substitution in the coding...
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