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Article

The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice.

The Journal of biological chemistry - 19 Nov 2004

Power Melanie R, Peng Yongde, Maydanski Elana, Marshall Jean S, Lin Tong-Jun

Abstract excerpt

Toll-like receptors (TLR) induce distinct patterns of host responses through myeloid differentiation factor 88 (MyD88)-dependent and/or -independent pathways, depending on the nature of the pathogen. Pseudomonas aeruginosa is a cause of serious lung infection in immunocompromised individuals and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15375173
DOI: 10.1074/jbc.M402111200

Genes

TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15375173-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice.PMID 15375173Read ↗

Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus.Semantic proximity Read ↗

The host control of a clinical isolate strain of P. aeruginosa infection is independent of Nod-1 but depends on MyD88.Semantic proximity Read ↗

Myeloid Differentiation Primary Response Gene (88)– and Toll‐Like Receptor 2–Deficient Mice Are Susceptible to Infection with Aerosolized<i>Legionella pneumophila</i>Semantic proximity Read ↗

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection.Semantic proximity Read ↗

Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila.Semantic proximity Read ↗

Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.Semantic proximity Read ↗

Aberrant inflammatory response to Streptococcus pyogenes in mice lacking myeloid differentiation factor 88.Semantic proximity Read ↗

Toll-like receptors are temporally involved in host defense.Semantic proximity Read ↗

Mice Lacking γδ T Cells Exhibit Impaired Clearance of Pseudomonas aeruginosa Lung Infection and Excessive Production of Inflammatory Cytokines.Semantic proximity Read ↗

MyD88-dependent signaling influences fibrosis and alternative macrophage activation during Staphylococcus aureus biofilm infection.Semantic proximity Read ↗

Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia.Semantic proximity Read ↗

Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system.Semantic proximity Read ↗

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