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Article

Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production.

The Journal of biological chemistry - 13 Jun 2008

Targett-Adams Paul, Hope Graham, Boulant Steeve, McLauchlan John

Abstract excerpt

Complete maturation of hepatitis C virus (HCV) core protein requires coordinate cleavage by signal peptidase and an intramembrane protease, signal peptide peptidase. We show that reducing the intracellular levels of signal peptide peptidase lowers the titer of infectious virus released from cells, indicating that it plays an important role in virus production. Proteolysis by the enzyme at a signal peptide between...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18424431
DOI: 10.1074/jbc.M802273200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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