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Article

The potential of signal peptide peptidase as a therapeutic target for hepatitis C.

Expert opinion on therapeutic targets - 1 Sept 2017

Moriishi Kohji

Abstract excerpt

INTRODUCTION: Chronic infection with hepatitis C virus (HCV) causes liver steatosis, cirrhosis, metabolic syndrome with inflammation, and eventually leads to hepatocellular carcinoma. HCV core protein is a well-known capsid protein and pathogenic factor related to lipid accumulation, type 2 diabetes mellitus, and carcinogenesis. Cleavage of the C-terminal transmembrane region by signal peptide peptidase (SPP) is...

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Identifiers

PMID: 28820612
DOI: 10.1080/14728222.2017.1369959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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