Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly.

The Journal of general virology - 1 Apr 2006

Ait-Goughoulte Malika, Hourioux Christophe, Patient Romuald, Trassard Sylvie, Brand Denys, Roingeard Philippe

Abstract excerpt

Hepatitis C virus (HCV) core protein, expressed with a Semliki Forest virus replicon, self-assembles into HCV-like particles (HCV-LP) at the endoplasmic reticulum (ER) membrane, providing an opportunity to study HCV assembly and morphogenesis by electron microscopy. This model was used to investigate whether the processing of the HCV core protein by the signal peptide peptidase (SPP) is required for the HCV-LP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid Endopeptidases
Share to Cricetinae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Hepacivirus

Share to Intracellular Membranes

Share to Viral Core Proteins

Share to Virion

Share to Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 16528035
DOI: 10.1099/vir.0.81664-0
PMCID: PMC2220033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly.PMID 16528035Read ↗

Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production.Semantic proximity Read ↗

Core protein domains involved in hepatitis C virus-like particle assembly and budding at the endoplasmic reticulum membrane.Semantic proximity Read ↗

Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation.Semantic proximity Read ↗

Characterization of the cleavage of signal peptide at the C-terminus of hepatitis C virus core protein by signal peptide peptidase.Semantic proximity Read ↗

The potential of signal peptide peptidase as a therapeutic target for hepatitis C.Semantic proximity Read ↗

Internally located signal peptides direct hepatitis C virus polyprotein processing in the ER membrane.Semantic proximity Read ↗

Characterization of hepatitis C virus core protein multimerization and membrane envelopment: revelation of a cascade of core-membrane interactions.Semantic proximity Read ↗

Signal Peptide Peptidase Cleavage of GB Virus B Core Protein Is Required for Productive Infection in VivoSemantic proximity Read ↗

The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion.Semantic proximity Read ↗

Mutation of the proteolytic cleavage site enhances stability and yield of recombinant hepatitis C virus core protein in bacterial cells.Semantic proximity Read ↗

Processing of the hepatitis E virus polyprotein can be mediated by a cellular proteaseSemantic proximity Read ↗

The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.