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5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children.

Pediatric blood & cancer - 1 Aug 2008

Alcasabas Patricia, Ravindranath Yaddanapudi, Goyette Gerard, Haller Andrew, Del Rosario Luz, Lesaca-Medina Maria Ysabel, Darga Linda, Ostrea Enrique M, Taub Jeffrey W, Everson Richard B

Abstract excerpt

BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism. Polymorphisms at the C677T and A1298C loci are associated with reduced activity; consequently more folate substrates are shunted toward thymidylate and DNA synthesis. Several studies have reported a reduced risk of developing ALL in children with MTHFR polymorphisms. The objective of this study was to determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 18421714
DOI: 10.1002/pbc.21511

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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