A3G-induced mutations show a low prevalence and exhibit plus-strand regional distribution in hepatitis B virus DNA from patients with non-hepatocellular carcinoma (HCC) and HCC.

Abstract excerpt

APOBEC3G (A3G) cytidine deaminase is an innate immune restriction factor that can edit and inhibit hepatitis B virus (HBV) replication. The preferred target of A3G is deamination of the third cytosine of 5'CCC to form a mutant marker 5'CC C → K. However, the distribution of A3G-induced mutations on HBV DNA during infection is not well characterized. To provide clarity, we obtained the HBV DNA sequences from HBV...

Topics

• APOBEC-3G Deaminase
• Carcinoma, Hepatocellular
• DNA, Viral
• Genotype
• Hepatitis B virus
• Humans
• Liver Neoplasms
• Mutation
• Prevalence
• Virus Replication