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Article

Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts.

Acta physiologica (Oxford, England) - 1 Oct 2008

Goddard C A, Ghais N S, Zhang Y, Williams A J, Colledge W H, Grace A A, Huang C L-H

Abstract excerpt

AIM: To explore the physiological consequences of the ryanodine receptor (RyR2)-P2328S mutation associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). METHODS: We generated heterozygotic (RyR2 p/s) and homozygotic (RyR2 s/s) transgenic mice and studied Ca2+ signals from regularly stimulated, Fluo-3-loaded, cardiac myocytes. Results were compared with monophasic action potentials (MAPs) in...

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Identifiers

PMID: 18419777
DOI: 10.1111/j.1748-1716.2008.01865.x
PMCID: PMC2628439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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