Article
Protein expression profiles in murine ventricles modeling catecholaminergic polymorphic ventricular tachycardia: effects of genotype and sex.
Annals of the New York Academy of Sciences - 1 Oct 2020
Saadeh Khalil, Achercouk Zakaria, Fazmin Ibrahim T, Nantha Kumar Nakulan, Salvage Samantha C, Edling Charlotte E, Huang Christopher L-H, Jeevaratnam Kamalan
Abstract excerpt
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is associated with mutations in the cardiac ryanodine receptor (RyR2). These result in stress-induced ventricular arrhythmic episodes, with clinical symptoms and prognosis reported more severe in male than female patients. Murine homozygotic RyR2-P2328S (RyR2S/S ) hearts replicate the proarrhythmic CPVT phenotype of abnormal sarcoplasmic reticular Ca2+...
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