Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant ryanodine receptors in catecholaminergic polymorphic ventricular tachycardia generate delayed afterdepolarizations due to increased propensity to Ca2+ waves.

European heart journal - 1 May 2007

Paavola Jere, Viitasalo Matti, Laitinen-Forsblom Päivi J, Pasternack Michael, Swan Heikki, Tikkanen Ilkka, Toivonen Lauri, Kontula Kimmo, Laine Mika

Abstract excerpt

AIMS: Mutations in cardiac ryanodine receptors (RyR2s) are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT), characterized by risk of polymorphic ventricular tachyarrhythmias and sudden death during exercise. Arrhythmias are caused by gain-of-function defects in RyR2, but ce...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Caffeine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Central Nervous System Stimulants

Share to Cyclic AMP

Share to Epinephrine

Share to Heart Conduction System

Share to Ryanodine Receptor Calcium Release Channel

Share to Tachycardia, Ventricular

Source

Identifiers

PMID: 17347175
DOI: 10.1093/eurheartj/ehl543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17347175-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant ryanodine receptors in catecholaminergic polymorphic ventricular tachycardia generate delayed afterdepolarizations due to increased propensity to Ca2+ waves.PMID 17347175Read ↗

Arrhythmogenic mechanisms in ryanodine receptor channelopathies.Semantic proximity Read ↗

Molecular and Electrophysiological Bases of Catecholaminergic Polymorphic Ventricular TachycardiaSemantic proximity Read ↗

Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations.Semantic proximity Read ↗

Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia.Semantic proximity Read ↗

Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia.Semantic proximity Read ↗

Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia.Semantic proximity Read ↗

Pathogenic mechanism of a catecholaminergic polymorphic ventricular tachycardia causing-mutation in cardiac calcium release channel RyR2.Semantic proximity Read ↗

Ryanodine receptor-mediated arrhythmias and sudden cardiac death.Semantic proximity Read ↗

Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?Semantic proximity Read ↗

Unraveling the mechanisms of catecholaminergic polymorphic ventricular tachycardia.Semantic proximity Read ↗

Slowed depolarization and irregular repolarization in catecholaminergic polymorphic ventricular tachycardia: a study from cellular Ca2+ transients and action potentials to clinical monophasic action potentials and electrocardiography.Semantic proximity Read ↗

Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.