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Article

Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue

17 Jul 2019

Abstract excerpt

Background: Modeling of human arrhythmias with induced pluripotent stem cell–derived cardiomyocytes has focused on single-cell phenotypes. However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of inherited arrhythmia mutations on tissue-level properties of human heart tissue has not been reported. Methods: Here, we report an optogenetically based, human engineered tissue...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 31311300
DOI: 10.1161/circulationaha.119.039711

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