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Article

Pathogenic mechanism of a catecholaminergic polymorphic ventricular tachycardia causing-mutation in cardiac calcium release channel RyR2.

Journal of molecular and cellular cardiology - 1 Apr 2018

Xiong Jing, Liu Xijun, Gong Yunyun, Zhang Peng, Qiang Sujing, Zhao Qian, Guo Rong, Qian Yunyun, Wang Lipeng, Zhu Li, Wang Ruiwu, Hao Zhiyuan, Wen Han, Zhang Jingying, Tang Kai, Zang Wang-Fu, Yuchi Zhiguang, Chen Haijun, Chen S R Wayne, Zheng Wenjun, Wang Shi-Qiang, Xu Ya-Wei, Liu Zheng

Abstract excerpt

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a condition that is characterized by an abnormal heart rhythm in response to physical or emotional stress. The majority CPVT patients carry mutations in the RYR2 gene that encodes the calcium release channel/ryanodine receptor (RyR2) in cardiomyocytes. The pathogenic mechanisms that account for the clinical phenotypes of CPVT are still elusive. We...

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Source

Identifiers

PMID: 29477366
DOI: 10.1016/j.yjmcc.2018.02.014

Genes

RYR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Pathogenic mechanism of a catecholaminergic polymorphic ventricular tachycardia causing-mutation in cardiac calcium release channel RyR2.PMID 29477366Read ↗

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