Tyr-701 is a new regulatory site for neurotrophin receptor TrkA trafficking and function.

doi:10.1111/j.1471-4159.2007.05027.x

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Article

Tyr-701 is a new regulatory site for neurotrophin receptor TrkA trafficking and function.

Journal of neurochemistry - 1 Jan 2008

de Pablo Yolanda, Pérez-García M José, Georgieva Maya V, Sanchis Daniel, Lindqvist Niclas, Soler Rosa M, Comella Joan X, Llovera Marta

Abstract excerpt

Tropomyosin-related kinase A (TrkA) receptor mediates the effects exerted by nerve growth factor on several subpopulations of neuronal cells. Ligand binding to TrkA induces receptor autophosphorylation on several tyrosine residues and the activation of signaling cascades. In this study, we describe a new site relevant for TrkA regulation, the tyrosine 701 (Y701), which is important for receptor trafficking and...

Topics

Adaptor Protein Complex gamma Subunits
Animals
Aspartic Acid
Cell Differentiation
Clathrin Heavy Chains
Immunoprecipitation
Lysosomal Membrane Proteins
Mutation
PC12 Cells
Protein Transport
Rats
Receptor, trkA
Transfection
Tyrosine

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Open in PubMed

Identifiers

PMID: 18173729
DOI: 10.1111/j.1471-4159.2007.05027.x

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