Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular genetic mechanisms of life span manipulation in Caenorhabditis elegans.

Annals of the New York Academy of Sciences - 1 Jun 2000

Murakami S, Tedesco P M, Cypser J R, Johnson T E

Abstract excerpt

Aging and a limited life span are fundamental biological realities. Recent studies have demonstrated that longevity can be manipulated and have revealed molecular mechanisms underlying longevity control in the soil nematode Caenorhabditis elegans. Signals from both neurons and the gonad appear to negatively regulate longevity. One tissue-specific signal involves an insulin-like phosphatidylinositol 3-OH kinase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Genes, Helminth
Share to Longevity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Source

Identifiers

PMID: 10911946
DOI: 10.1111/j.1749-6632.2000.tb06634.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular genetic mechanisms of life span manipulation in Caenorhabditis elegans.PMID 10911946Read ↗

Genetics, life span, health span, and the aging process in Caenorhabditis elegans.Semantic proximity Read ↗

Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.Semantic proximity Read ↗

Life span: getting the signal from the nervous system.Semantic proximity Read ↗

Signals from the reproductive system regulate the lifespan of C. elegans.Semantic proximity Read ↗

Studies of Caenorhabditis elegans DAF‐2/insulin signaling reveal targets for pharmacological manipulation of lifespanSemantic proximity Read ↗

Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in Caenorhabditis elegans.Semantic proximity Read ↗

The determinants of lifespan in the nematode Caenorhabditis elegans: a short primer.Semantic proximity Read ↗

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.Semantic proximity Read ↗

Longevity determined by developmental arrest genes in Caenorhabditis elegans.Semantic proximity Read ↗

Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegansSemantic proximity Read ↗

Regulation of C. elegans life-span by insulinlike signaling in the nervous system.Semantic proximity Read ↗

Long-lived worms and aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.