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Article

Probing the structures of leishmanial farnesyl pyrophosphate synthases: homology modeling and docking studies.

Journal of chemical information and modeling - 1 May 2008

Mukherjee Prasenjit, Desai Prashant V, Srivastava Anuradha, Tekwani Babu L, Avery Mitchell A

Abstract excerpt

Leishmania donovani and Leishmania major farnesyl pyrophosphate synthase ( LdFPPS and LmFPPS) are potential targets for the development of antileishmanial therapy. The protein sequence for LdFPPS was recently elucidated in our laboratory. Highly refined homology models were generated using the protein sequences of LdFPPS and the closely related LmFPPS enzyme. A ligand-refined model of LmFPPS with a bound...

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Identifiers

PMID: 18419114
DOI: 10.1021/ci700355z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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