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Article

Structural exploration of glutamine synthetase from Leishmania donovani: Insights from in silico and in vitro analysis.

International journal of biological macromolecules - 1 Mar 2020

Kumar Vinay, Sushma Sri N, Tripathi Neha, Sharma Vishnu K, Bharatam Prasad V, Garg Prabha, Singh Sushma

Abstract excerpt

Glutamine synthetase from L. donovani (LdGS) has been identified as a potential antileishmanial target in our previous report based on biochemical and inhibition studies. With the aim to structurally explore LdGS, systematic in silico and in vitro studies have been employed in the present study to identify amino acids crucial for LdGS mediated catalysis. A comparative analysis with human GS (HsGS) was performed...

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Identifiers

PMID: 31726137
DOI: 10.1016/j.ijbiomac.2019.09.209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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