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Article

Bisphosphonate Inhibition of the Exopolyphosphatase Activity of theTrypanosoma bruceiSoluble Vacuolar Pyrophosphatase

25 Aug 2005

Abstract excerpt

Trypanosoma brucei, the causative agent of African trypanosomiasis, contains a soluble, vacuolar pyrophosphatase, TbVSP1, not present in humans, which is essential for the growth of bloodstream forms in their mammalian host. Here, we report the inhibition of a recombinant TbVSP1 expressed in Escherichia coli by a panel of 81 bisphosphonates. The IC50 values were found to vary from approximately 2 to 850 microM....

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PMID: 16162013
DOI: 10.1021/jm058220g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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