Article
Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency.
The Journal of allergy and clinical immunology - 1 Jun 2014
Salzer Elisabeth, Kansu Aydan, Sic Heiko, Májek Peter, Ikincioğullari Aydan, Dogu Figen E, Prengemann Nina Kathrin, Santos-Valente Elisangela, Pickl Winfried F, Bilic Ivan, Ban Sol A, Kuloğlu Zarife, Demir Arzu Meltem, Ensari Arzu, Colinge Jacques, Rizzi Marta, Eibel Hermann, Boztug Kaan
Abstract excerpt
BACKGROUND: Alterations of immune homeostasis in the gut can result in development of inflammatory bowel disease (IBD). Recently, Mendelian forms of IBD have been discovered, as exemplified by deficiency of IL-10 or its receptor subunits. In addition, other types of primary immunodeficiency disorders might be associated with intestinal inflammation as one of their leading clinical presentations. OBJECTIVE: We...
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