Article
Distant segments of Saccharomyces cerevisiae scR1 RNA promote assembly and function of the signal recognition particle.
Journal of molecular biology - 4 May 2007
van Nues Rob W, Brown Jeremy D
Abstract excerpt
The conserved signal recognition particle targets ribosomes synthesizing presecretory proteins to the endoplasmic reticulum membrane. Key to the activity of SRP is its ability to bind the ribosome at distant locations, the signal sequence exit and elongation factor-binding sites. These contacts are made by the S and Alu domains of SRP, respectively. We tested earlier secondary structure predictions of the...
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