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Article

Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.

Journal of molecular cell biology - 1 Jun 2017

Gao Yina, Zhang Qi, Lang Yue, Liu Yang, Dong Xiaofei, Chen Zhenhang, Tian Wenli, Tang Jun, Wu Wei, Tong Yufeng, Chen Zhongzhou

Abstract excerpt

The co-translational targeting or insertion of secretory and membrane proteins into the endoplasmic reticulum (ER) is a key biological process mediated by the signal recognition particle (SRP). In eukaryotes, the SRP68-SRP72 (SRP68/72) heterodimer plays an essential role in protein translocation. However, structural information on the two largest SRP proteins, SRP68 and SRP72, is limited, especially regarding...

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Source

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Identifiers

PMID: 28369529
DOI: 10.1093/jmcb/mjx010
PMCID: PMC5907831

Genes

SRP68
SRP72
TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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