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Article

Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of Srp54p.

Nucleic acids research - 11 Jul 1994

Selinger D, Brennwald P, Althoff S, Reich C, Hann B, Walter P, Wise J A

Abstract excerpt

Mammalian signal recognition particle (SRP), a complex of six polypeptides and one 7SL RNA molecule, is required for targeting nascent presecretory proteins to the endoplasmic reticulum (ER). Earlier work identified a Schizosaccharomyces pombe homolog of human SRP RNA and showed that it is a component of a particle similar in size and biochemical properties to mammalian SRP. The recent cloning of the gene...

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Identifiers

PMID: 8041618
DOI: 10.1093/nar/22.13.2557
PMCID: PMC308210

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Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of Srp54p.PMID 8041618Read ↗

Identification of RNA sequences and structural elements required for assembly of fission yeast SRP54 protein with signal recognition particle RNA.Semantic proximity Read ↗

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The signal recognition particle in S. cerevisiae.Semantic proximity Read ↗

Binding site of the M-domain of human protein SRP54 determined by systematic site-directed mutagenesis of signal recognition particle RNA.Semantic proximity Read ↗

Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export.Semantic proximity Read ↗

Systematic mutagenesis of the fission yeast Srp54 protein.Semantic proximity Read ↗

Roles for Srp72p in assembly, nuclear export and function of the signal recognition particle.Semantic proximity Read ↗

A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins.Semantic proximity Read ↗

Random mutagenesis of Schizosaccharomyces pombe SRP RNA: lethal and conditional lesions cluster in presumptive protein binding sites.Semantic proximity Read ↗

Elongation arrest is a physiologically important function of signal recognition particle.Semantic proximity Read ↗

Assembly of the human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control.Semantic proximity Read ↗

Nuclear export of yeast signal recognition particle lacking Srp54p by the Xpo1p/Crm1p NES-dependent pathway.Semantic proximity Read ↗

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