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Article

Access to ribosomal protein Rpl25p by the signal recognition particle is required for efficient cotranslational translocation.

Molecular biology of the cell - 1 Jul 2008

Dalley Jane A, Selkirk Alexander, Pool Martin R

Abstract excerpt

Targeting of proteins to the endoplasmic reticulum (ER) occurs cotranslationally necessitating the interaction of the signal recognition particle (SRP) and the translocon with the ribosome. Biochemical and structural studies implicate ribosomal protein Rpl25p as a major ribosome interaction site for both these factors. Here we characterize an RPL25GFP fusion, which behaves as a dominant mutant leading to defects...

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Identifiers

PMID: 18448667
DOI: 10.1091/mbc.e07-10-1074
PMCID: PMC2441686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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