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Article

Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk?

1 May 2008

Abstract excerpt

Studies on the protective role of dietary fiber and its breakdown product butyrate against colorectal cancer (CRC) have yielded inconsistent findings. We have reported that butyrate treatment of CRC cells in vitro modulates canonical Wnt signaling, a pathway which is constitutively activated in the majority of CRCs. Analyses of ten human CRC cell lines exposed to butyrate have established that the levels of...

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PMID: 18418037
DOI: 10.4161/cc.7.9.5818

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