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The importance of colonic butyrate transport to the regulation of genes associated with colonic tissue homoeostasis

1 Aug 2005

Abstract excerpt

The transition from normality to malignancy in colorectal cancer is characterized by alterations in the expression of genes associated with the maintenance of tissue homoeostasis. Butyrate, a product of microbial fermentation of dietary fibre in the colon, is known to regulate a number of genes associated with the processes of proliferation, differentiation and apoptosis of colonic epithelial cells, and, hence,...

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Identifiers

PMID: 16042588
DOI: 10.1042/bst0330733

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